Endocrine Abstracts

Introduction: Papillary thyroid carcinoma is well known as a differentiated thyroid carcinoma with an established treatment protocol and high survival rates. Poorly differentiated thyroid carcinoma, or anaplastic, is highly aggressive, manifesting with local invasion, recurrence, and distant metastasis; it is well known that these two entities may be connected as a process of dedifferentiation, most commonly met in elderly people with a long term standing untreated well differ...

Introduction: We report a case of a pituitary insufficiency apparently resistant to treatment.Case report: A 74 year old patient was admitted through the ER in our department for a recently discovered pituitary macroadenoma. His general condition was poor in spite of the initiation of corticotherapy. Evaluation: Smoker, with no significant medical history, the BP: 100/60 mmHg, no orthostatic hypotension, disoriented, confused, with moderately altered gen...

Background: Pituitary surgery is the first treatment option for acromegaly. The reported success of pituitary surgery varies between 75 and 95% for microadenomas and 45 and 68% for macroadenomas. The aim of this study was to report our experience regarding the remission rate after pituitary surgery in acromegaly patients.Methods: This retrospective study included 70 patients diagnosed with acromegaly in our clinic between 2009 and 2016. The criteria used...

Objective: The aim of this retrospective study is to evaluate the bone status in patients receiving oncological treatment, like radiation, chemotherapy, adjunctive therapies, and surgery.Material and methods: Medical records of 102 womens (mean age 59.12 yrs) with breast cancer history reffered for endocrine evaluation were retrospectivelly analysed. Demographic data, bone densitometry parameters, prevalent fractures and antineoplastic treatments history...

Introduction: Endocrinopathies are a common late effect of haematopietic stem cell transplantation, resulting in thyroid dysfunction, impaired growth and pubertal development during childhood and metabolic syndrome. Because of the possible endocrine complications, transplanted patients need life-long endocrine follow-up.Case report: A 14-year-old male patient with a history of Fanconi anemia (7 years), bone marrow transplant (10 years) and Graves Disease...

Introduction: While the unfavourable metabolic consequences of obesity have been clearly demonstrated at a population level, there is a wealth of evidence indicating the existence of individuals somehow protected from developing complications, named ‘metabolically healthy obese’. The aim of our study was to identify clinical and biological parameters independently associated with ‘metabolically healthy’ status.Patients and methods: 44...

Introduction: Osteopenia/osteoporosis in young adults with β-thalassemia major (BTM) is a prominent cause of morbidity despite adequate transfusion and iron chelation therapy. The reported frequency of osteoporosis, even in well treated TM patients varies from 13.6% to 50%, with an additional 45% affected by osteopenia.Case report: We present the case of a 36-years-old male patient with BTM treated for 1 year with teriparatide for osteoporosis. Our ...

Aim of the study was to evaluate the relationship between biochemical bone turnover markers, calcium homeostasis parameters and the cardiovascular risk in patients with osteoporosis.Materials and methods: Subjects were 246 patients (mean age of 56.64) diagnosed with osteoporosis referred to the endocrine department of Elias Hospital, between 2009 and 2013, and who agreed with the terms of the study. Data collection consisted of clinica...

Introduction: Therapeutic management of clinical nonsecreting pituitary adenomas with ophthalmological manifestations is certainly limited to surgery unless IHC from previous intervention could bring up new data.Case report: A 16-year-old patient was admitted in February 2014 in our Endocrinology Department for short stature (−3.5 S.D.), in the context of an iatrogenic pituitary insufficiency. 7 months before, he had been diagnosed w...

Background and Aim: Non-functioning pituitary adenomas (NFPAs) are hormonally inactive adenohypophyseal tumors. The absence of hormone hypersecretion and the lack of clinical manifestations delay the diagnosis and therefore symptoms of mass effect are frequently seen in NFPAs. The primary endpoint of this study was to evaluate the clinical presentation of patients with NFPAs and their therapeutic management. The secondary endpoint was to identify how gender and tumor size impa...